Cellular Energetics: Actin and Myosin Abstain from ATP during Starvation

نویسندگان

  • Destiney Buelto
  • Mara C. Duncan
چکیده

2. Erwin, D.H., Laflamme, M., Tweedt, S.M., Sperling, E.A., Pisani, D., and Peterson, K.J. (2011). The Cambrian conundrum: early divergence and later ecological success in the early history of animals. Science 334, 1091–1097. 3. Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214. 4. Clemente, J.C., Ursell, L.K., Parfrey, L.W., and Knight, R. (2012). The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258–1270. 5. Underhill, D.M., and Iliev, I.D. (2014). The mycobiota: interactions between commensal fungi and the host immune system. Nat. Rev. Immunol. 14, 405–416. 6. Morales, D.K., and Hogan, D.A. (2010). Candida albicans interactions with bacteria in the context of human health and disease. PLoS Pathog. 6, e1000886. 7. Peleg, A.Y., Hogan, D.A., and Mylonakis, E. (2010). Medically important bacterial-fungal interactions. Nat. Rev. Microbiol. 8, 340–349. 8. Fox, E.P., Cowley, E.S., Nobile, C.J., Hartooni, N., Newman, D.K., and Johnson, A.D. (2014). Anaerobic bacteria grow within Candida albicans biofilms and induce biofilm formation in suspension cultures. Curr. Biol. 24, 2411–2416. 9. Mitchell, A.P. (1998). Dimorphism and virulence in Candida albicans. Curr. Opin. Microbiol. 1, 687–692. 10. Berman, J., and Sudbery, P.E. (2002). Candida Albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. Genet. 3, 918–930. 11. Naglik, J.R., Fidel, P.L., Jr., and Odds, F.C. (2008). Animal models of mucosal Candida infection. FEMS Microbiol. Lett. 283, 129–139. 12. Finkel, J.S., and Mitchell, A.P. (2011). Genetic control of Candida albicans biofilm development. Nat. Rev. Microbiol. 9, 109–118. 13. Davey, M.E., and O’Toole, G.A. (2000). Microbial biofilms: from ecology to molecular genetics. Microbiol. Mol. Biol. Rev. 64, 847–867. 14. Costerton, J.W., Stewart, P.S., and Greenberg, E.P. (1999). Bacterial biofilms: a common cause of persistent infections. Science 284, 1318–1322. 15. Harriott, M.M., and Noverr, M.C. (2011). Importance of Candida-bacterial polymicrobial biofilms in disease. Trends Microbiol. 19, 557–563. 16. Bradshaw, D.J., Marsh, P.D., Allison, C., and Schilling, K.M. (1996). Effect of oxygen, inoculum composition and flow rate on development of mixed-culture oral biofilms. Microbiology 142, 623–629. 17. Rossignol, T., Ding, C., Guida, A., d’Enfert, C., Higgins, D.G., and Butler, G. (2009). Correlation between biofilm formation and the hypoxic response in Candida parapsilosis. Eukaryot. Cell 8, 550–559. 18. Stichternoth, C., and Ernst, J.F. (2009). Hypoxic adaptation by Efg1 regulates biofilm formation by Candida albicans. Appl. Environ. Microbiol. 75, 3663–3672. 19. Nobile, C.J., Fox, E.P., Nett, J.E., Sorrells, T.R., Mitrovich, Q.M., Hernday, A.D., Tuch, B.B., Andes, D.R., and Johnson, A.D. (2012). A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148, 126–138.

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عنوان ژورنال:
  • Current Biology

دوره 24  شماره 

صفحات  -

تاریخ انتشار 2014